Application

C18 Ceramide-d7 (d18:1-d7/18:0) has been used as a standard in liquid chromatography–mass spectrometry (LC-MS) for quantitative analysis of C18 ceramide in skeletal muscle. It has also been used as a standard to measure C35–C39 ceramides in zebrafish brain and human embryonic kidney cell line (HEK293) by thermo q-exactive plus quadrupole-orbitrap mass spectrometery.

Biochem/physiol Actions

C18 ceramide is involved in cell growth inhibition. Determining the levels of the ceramides (Cer) d18:1/16:0, Cer d18:1/18:0, Cer d18:1/24:0, and Cer d18:1/24:1 and ratios in human plasma enables the prognosis of fatal outcome of coronary artery disease. Stable isotope form of C18 ceramide d18:1/18:0 supports a newly described validated liquid chromatography-tandem mass spectrometry methodology for their clinical-scaled measurement.

General description

C18 Ceramide (d18:1/18:0) is a synthetic ceramide containing sphingosine with stearic acid. C18 Ceramide-d7 (d18:1-d7/18:0) is a deuterated derivative of ceramide d18:1/18:0.

Packaging

5 mL Amber Glass Screw Cap Vial (860677P-1mg)