Application

18:1-d7 Lyso PC has been used:as an internal standard in high performance liquid chromatography electrospray ionization tandem mass spectrometry (HPLC-ESIMS/MS) for the lipidomics analysis of bone marrow-derived macrophagesas a component of extraction solvent for lipid isolation from biological samplesas an internal standard for spiking serum samples for liquid chromatography with tandem mass spectrometry (LC-MS/MS)

Biochem/physiol Actions

Lysophosphatidylcholine (LPC). Elevated levels of LPC is associated with diabetes and cardiovascular diseases. LPC stimulates cytokines and is implicated in allergic disease. It also elicits lysis on membranes.

General description

18:1-d7 Lyso PC 1-oleoyl(d7)-2-hydroxy-sn-glycero-3-phosphocholine is a deuterated phospholipid. The lipid lysophosphatidylcholine is esterified with oleic acid. Oleic acid harbors the deuterium ions. Lysophosphatidylcholine (LPC) is derived from phosphatidylcholineby the action of enzyme phospholipase A2.

This deuterium labeled lipid is also available in a formulation of multiple lipid standards. The SPLASH^® LIPIDOMIX^® Standard includes all of the major lipid classes at ratios relative to human plasma, allowing one easy internal standard solution to be added to every sample.

Legal Information

SPLASH is a registered trademark of Avanti Polar Lipids, Inc.

LIPIDOMIX is a registered trademark of Avanti Polar Lipids, Inc.

Packaging

5 mL Clear Glass Sealed Ampule (791643C-1mg)