Macrophage colony-stimulating factor (M-CSF) is a cytokine that regulates the survival, proliferation, differentiation, and functional activation of monocytes, such as macrophages and dendritic cells.
M-CSF has been used in vitro for the differentiation of human induced pluripotent stem cell (iPSC)-derived macrophages as well as the maintenance and development of monocytes in hematopoietic stem cell culture. M-CSF has also been used to influence macrophage polarization towards an anti-inflammatory or M2 macrophage phenotype.
Qkine M-CSF is a highly bioactive, animal origin-free (AOF), carrier protein-free 36.8 kDa recombinant protein with exceptional lot-to-lot consistency.
- High purity human M-CSF protein (Uniprot: P09603)
- >98%, by SDS-PAGE quantitative densitometry
- Expressed in E. coli
- 36 kDa dimer
- Animal origin-free (AOF)
- Carrier protein-free
- Manufactured in our Cambridge, UK laboratories
- Lyophilised from acetonitrile/TFA
- Resuspend in 10mM HCl, prepare single-use aliquots, add carrier protein if desired and store frozen at -20°C or -80°C