Qkine Recombinant Human R-Spondin 1 LR5 Protein - 100uG

Name: Qkine Recombinant Human R-Spondin 1 LR5 Protein - 100uG
Brand: QKINE
SKU: PRO1184
Price: 442.00 EUR
Availability: InStock

Code: PRO1184 D2-0

Recombinant human R-spondin 1 LR5 protein is engineered to act as a high affinity ligand for the LGR5 receptor. In epithelial tissues LGR5 marks the stem cell population. This engineered protein,...

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OVERVIEW
SUSTAINABILITY

Recombinant human R-spondin 1 LR5 protein is engineered to act as a high affinity ligand for the LGR5 receptor. In epithelial tissues LGR5 marks the stem cell population. This engineered protein, R-spondin 1 LR5, activates Wnt signalling only in the LGR5+ stem cell population.

R-spondin 1 LR5 has been tested in intestinal organoid culture and supports organoid survival and growth. As LGR5 specifically marks stem cells and is not found on transit amplifying cells, the lower crypt multiplicity seen in organoid cultures with R-spondin 1 LR5 (in comparison to wild-type R-spondin 1, Qk006) supports the notion that this engineered form is acting specifically on stem cells.

High purity recombinant human R-spondin 1 LR5 protein. Binds with higher affinity to LGR5 receptor
>98%, by SDS-PAGE quantitative densitometry
13 kDa
Expressed in E. coli
Animal origin-free (AOF) and carrier protein-free
Manufactured in our Cambridge, UK laboratories
Lyophilised from acetonitrile, TFA
Resuspend in 10mM HCl at >100µg/mL (provided with protein and free of charge), prepare single use aliquots, add carrier protein if desired and store frozen at -20°C or -80°C

This product has met the following criteria to qualify for the following awards:

	Sustainable Raw Material	Designed to reduce the use of raw materials
	Sustainable Product Manufacturing	Measures were in place during the manufacture of this product to reduce energy consumption Measures were in place during the manufacture of this product to generate less waste Measures were in place during the manufacture of this product to reduce water usage Aligns with the principles of green chemistry
	Sustainable Distribution & Packaging	Manufactured in the UK or Ireland Country of origin has an Environmental Performance Index (EPI) greater than 60 Plastic free packaging Product reduces need for packaging
	Sustainable Use	Product contributes to a reduced energy consumption Product contributes to a reduced water consumption Product reduces or replaces the need for consumables Built to last – minimum 5-year warranty, and spare part/servicing available
	Sustainable Disposal	A feature of this product enhances its biodegradability