Daunorubicin hydrochloride, meets USP testing specifications

Code: D8809-1MG D2-231

Biochem/physiol Actions

Potent anticancer agent. Inhibits DNA and RNA synthesis as sequence specific ds-DNA intercalating agent.

Naturally fluorescent anthracycline ant...


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€63.30 1MG
€77.86 inc. VAT
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Biochem/physiol Actions

Potent anticancer agent. Inhibits DNA and RNA synthesis as sequence specific ds-DNA intercalating agent.

Naturally fluorescent anthracycline antibiotic, anticancer drug. Substrate for Pgp, MRP-1 and BCRP. Fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles (golgi and lysosome) in the sequestration of drugs and its implication in drug resistant phenotypes. Daunorubicin is sequestered into lysosomes according to a pH partitioning type mechanism. Strong inhibitor of DNA and RNA synthesis.

Packaging

1, 10 mg in glass bottle

50 mg in poly bottle

agencymeets USP testing specifications, USP/NF
antibiotic activity spectrumneoplastics
formsolid
Gene Informationhuman ... TOP2A(7153)
InChI keyGUGHGUXZJWAIAS-QQYBVWGSSA-N
InChI1S/C27H29NO10.ClH/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33;/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3;1H/t10-,14-,16-,17-,22+,27-;/m0./s1
mode of actionDNA synthesis | interferes
Quality Level200
SMILES stringCl.COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(C)=O
storage temp.2-8°C
Cas Number23541-50-6
Hazard Class6.1
Un Number2811
Pack GroupIII
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