E-64d, protease inhibitor

Code: E8640-250UG D2-231

Application

E-64d has been used as a lysosomal inhibitor in human acute promyelocytic leukemia NB4 cells and Huh-7cells. It has also been used as a protease inhibitor in free...


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€148.10 250UG
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Application

E-64d has been used as a lysosomal inhibitor in human acute promyelocytic leukemia NB4 cells and Huh-7cells. It has also been used as a protease inhibitor in free calcium physiological tyrode solution for perfusion into the isolated heart samples.

Biochem/physiol Actions

E-64d is an epoxysuccinyl peptide and an inhibitor of cysteine protease cathepsin B, calpains 1 and 2. E-64d by its cathepsin B protease inhibition functionality, may serve as a potential drug for treating traumatic brain injury (TBI) and Alzheimer′s disease (AD). It inhibits gametocyte surface antigen resulting in a decreased oocyst production in Plasmodium falciparum.

assay≥98% (TLC)
biological sourcesynthetic (organic)
formpowder
Gene Informationhuman ... CAPN1(823)
InChI keySRVFFFJZQVENJC-IHRRRGAJSA-N
InChI1S/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12-,13-,14-/m0/s1
Quality Level200
SMILES stringCCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCCC(C)C
solubilitymethanol: water (1:1): 5 mg/mL, clear, colorless
storage temp.−20°C
Cas Number88321-09-9
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