Application

Ligand utilized in amination of aryl halides and aryl triflates.Catalyst for: Decarboxylative cross-coupling of dialkoxybenzoic acids with diaryl disulfides or diaryl diselenides Stereoselective preparation of imidazolidinones via intramolecular hydroamination of N-allylic-N-arylureas Regioselective arylation of olefins with aryl chlorides Cross-coupling reaction for the synthesis of polyunsaturated macrolactones Regioselective O-alkylation reactions Sonogashira-type cross coupling

JohnPhos, a bulky phosphine ligand, was employed as catalyst in the following studies:Hydrophenoxylation of unactivated internal alkynes.Microwave-mediated Suzuki-Miyaura cross-coupling of benzylic bromides.Pharmaceutical synthesis of novel imidazo[1,2-a]pyridines, having potent activity against the herpes virus.Barluenga′s coupling of vinyl bromides with hydrazines.Pd-catalyzed 2,3-diarylation of α,α-disubstituted-3-thiophenemethanols, via cleavage of C-H and C-C bonds.

Bulky biarylphosphine ligand utilized in the palladium catalyzed Stille cross-coupling reaction.

General description

JohnPhos is a Buchwald′s sterically bulky biaryl phosphine ligand. It is a reactive dialkylbiaryl phosphine ligand which catalyzes the carbon-nitrogen bond-forming reactions. Coordination chemistry of gold catalysts bearing JohnPhos as ligand has been investigated by NMR spectroscopy.

Packaging

1, 5, 25, 100 g in glass bottle