Application

tBuXPhos is a ligand for Pd-catalyzed C-O and C-N bond formation.It can be used in the following reactions:Palladium-catalyzed Tsuji-Trost substitution and cross-coupling of benzylic fluorides.Palladium-catalyzed C-N cross-coupling of sulfinamides and aryl halides.Palladium-catalyzed rapid methoxylation and deuteriomethoxylation of bromo-chalcones.

tBuXPhos has been used in the preparation of [tBuXPhosAu(MeCN)]BAr₄F, a gold catalyst for the intermolecular [2+2] cycloaddition of terminal arylalkynes with substituted alkenes to form functionalized cyclobutenes with high regioselectivity.

General description

tBuXPhos [2-Di-tert-butylphosphino-2′,4′,6′-triisopropylbiphenyl] is an air-stable, electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions.

Legal Information

Usage subject to Patents: EP 1097158; JP 5758844; CA 2336691

Packaging

1, 5, 25, 100, 500 g in glass bottle