Analysis Note

Colour (visual): white to yellow to beigeAppearance of substance (visual): beadsLoading (determined from the substitution of the Fmoc-Leu loaded resin): 0.20 - 0.30 mmol/gSwelling Volume (in CH₂Cl₂): lot specific result

General description

NovaSyn™ TG PAP resin contains an acid cleavable linkage between the polystyrene matrix and the PEG chain. Treatement of peptides prepared on this resin with TFA/thioanisole (95:5) for 12 hours or TMSBr/TFA/thioanisole (1:94:5) for 60 minutes releases a fully deprotected peptide possessing a PEG-chain attached to the C-terminus [1]. Such peptide-PEG conjugates can be used directly as immunogens, without the need for a carrier protein. The peptide-PEG conjugates are also highly soluble and provide an effective solution to insoluble peptides.

Legal Information

NOVASYN is a registered trademark of Merck KGaA, Darmstadt, Germany

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany