Analysis Note

Color (visual): white to yellow to beigeAppearance of substance (visual): beadsSwelling Volume (in DMF): lot specific resultLoading (determined by elemntal analysis of bromine): 0.80 - 1.30 mmol/gThe polymer matrix is copoly (styrene - 1 % DVB), 100 - 200 mesh

General description

This versatile support is an excellent tool for the solid phase immobilization of carboxylic acids, amines and alcohols. Acids are attached by treating the resin with the appropriate DIPEA salt in DMF in the presence of CsI [1,2]. Reaction with aryl and alkyl amines provides resin-bound secondary amines. These can be readily acylated to give sulfonamides or anilides that can be cleaved with 95% TFA. Since this resin does not contain a benzylic ether linkage, it gives cleaner products than similar supports derived from Wang resin, free from impurities arising from breakdown of the linker. For examples using a similar resin, please see [1-4].

The product number for this product was previously 01-64-0400.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Linkage

Replaces: 01-64-0400