Analysis Note

Color (visual): white to yellow to beigeAppearance of substance (visual): beadsLoading (determined by elemental analysis of sulfur after coupling with tosylhydrazide): 0.60 - 1.20 mmol/gSwelling Volume (in DMF): lot specific resultThe polymer matrix is copoly (styrene-1% DVB), 100 - 200 mesh

General description

Versatile indole-based linker for the synthesis of secondary amides, carbamates, ureas [1-4] and aminopurines [5]. In a study comparing the cleavage rates of secondary amides, ureas, carbamates and sulfonamides from indole, dialkoxybenzaldehyde and Rink amide resins, the indole resin was found to be the most acid-labile [6].

Reductive amination with excess of amine and NaBH(OAc)₃ in DCE/TMOF [see page], NaBH₃CN in THF/TMOF/AcOH, or NaBH₄-Ti(OiPr)₄ in THF [2], converts the formyl group to the appropriate secondary amine. Cleavage can be effected with 2-5 % TFA in DCM, depending on the nature of the product being released from the resin.

The product number for this product was previously 01-64-0361.

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Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Linkage

Replaces: 01-64-0361