Analysis Note

Color (visual): slight yellow to beigeAppearance of substance (visual): beadsLoading (determined from the substitution of the Fmoc-Gly-ol loaded resin): 0.70 - 1.20 mmol/gSwelling Volume (in CH₂Cl₂): lot specific resultThe polymer matrix is copoly (styrene-1% DVB), 100 - 200 mesh

General description

A highly versatile support for the solid phase immobilization of primary, secondary alcohols [1-11], phenols [12], purines [13], and indoles [14]. Derivatization is effected by treating the support in DCM with an excess of alcohol in the presence of a catalytic amount of pyridinium p-toluenesulfonate. A similar DHP-based support has also been used for the immobilization of tetrazoles [15].

Release of the product alcohol from the support has been carried out by treating with 95% TFA/5% water [1] and TFA/DCM/EtOH [2, 12]. However, the use of TFA can lead, in some cases, to trifluoroacetate formation. Methods which eliminate this potential side reaction include PPTS/BuOH/DCE [3], TosOH in DCM [16] and TosOH in DCE/BuOH [17].

The product number for this product was previously 01-64-0192.

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Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Linkage

Replaces: 01-64-0192