Analysis Note
Color (visual): white to yellow to beigeAppearance of substance (visual): beadsLoading (determined from the substitution of the Fmoc-Leu loaded resin): 0.60 - 1.60 mmol/gSwelling Volume (in DMF): lot specific resultThe polymer matrix is copoly (styrene - 1% DVB) 100 -200 mesh
General description
This resin is ideal for the solid phase immobilization of carboxylic acids. Less cross-linking is observed than with Merrifield resin during the attachment of diacids [1]. Reaction with a suitable phosgene equivalent converts this resin to a support suitable for the immobilization of amines [2].
Release of carboxylic acids from this support is normally effected by treatment of the resin with HF or TFMSA, or by hydrogenolysis [3]. Alcohols can be liberated by reduction with DIBAL [4] or LiBH4 [5]. Methyl esters can be produced by transesterification with MeONa [6] or Ti(OEt)4/C2H5CO2Me [7]. Carboxamides are also accessible via Lewis acid catalyzed aminolysis [8].
The product number for this product was previously 01-64-0110.
To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”.
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
Linkage
Replaces: 01-64-0110
Packaging
25 g in Plastic bottle
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