Analysis Note

Color (visual): white to slight yellow to beigeAppearance of substance (visual): powderIdentity (IR): passes testEnantiomeric purity: ≥ 99.0 % (a/a)Purity (TLC(011A)): ≥ 97 %Assay (HPLC, area%): ≥ 97.0 % (a/a)Water (K. F.): ≤ 2.0 %For TLC-Systems see our General Catalog

General description

A modified lysine derivative for the preparation of fluorogenically-labeled peptides by Fmoc chemistry [1].

The Mca group fluoresces at 405 nm when stimulated at 340 nm, and is most commonly used in conjunction with Dabcyl and 2,4-dinitrophenyl quenching groups.

Recently, Fmoc-Lys(Mca)-OH has been used to prepare lanthanide-based luminescent proteins by native chemical ligation [2]. Lys(Mca) was found to be stable to HF cleavage conditions used to synthesize the thioester fragments needed for ligation.

The product number for this product was previously 04-12-1233.

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Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Linkage

Replaces: 04-12-1233