Analysis Note

Color (visual): white to off whiteAppearance of substance (visual): powderIdentity (IR): passes testEnantiomeric purity: ≥ 99.5 % (a/a)Purity (TLC(011A)): ≥ 95 %Assay (HPLC, area%): ≥ 96.0 % (a/a)Solubility (1 mmole in 2 ml CH₂Cl₂): clearly solubleAssay (acidimetric): ≥ 90.0 %For TLC-Systems see our General Catalog

General description

Hmb protection of amide bonds has been shown to inhibit aggregation of ′difficult′ peptides, thereby leading to products of increased purity [1-6]. Retention of Hmb groups on the cleaved peptide can greatly improve the solubility of protected peptide fragments [7, 8] and otherwise intractable sequences [9-11]. Furthermore, using a Hmb-protected derivative for incorporation of the residue linked to the carboxy group of Asp or Asn residues has been found to suppress formation of aspartimide and piperidide related by-products [12-14]. For a comparison of the efficiency of Hmb and pseudoprolines in preventing aggregation, see [15].

The product number for this product was previously 04-12-1129.

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Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Linkage

Replaces: 04-12-1129

Packaging

5 g in Glass bottle