Paramagnetic SPRI beads designed for clean-up and size selection of DNA fragments or next generation sequencing (NGS) libraries. Paramagnetic beads selectively bind DNA fragments based on the volume ratio of bead suspension and sample. They are capable of delivering highly purified DNA fragments and efficiently removing contaminants, such as nucleotides, primers, adapters, enzymes, buffer additives, and salts.

NGS Clean and Select Beads is an efficient NGS library preparation clean-up and selection system based on paramagnetic beads. It is designed for the removal of salts, primers, and dNTPs and size selection of DNA fragments that can be used directly for downstream applications. The protocol can be used manually or adapted for liquid handling workstations.

• Consistent bead diameter for highly reproducible selection of the user-defined fragment size range
• Excellent recovery of fragments greater than 100 bp and efficient removal of all contaminants
• Eliminates centrifugation or filtration steps for fast manual processing and simple integration with automated liquid handling platforms
• Bead composition specifically developed to withstand the rigours of the NGS workflow