DL-3-Hydroxy-3-methylglutaryl coenzyme A sodium salt hydrate, >=90% (HPLC)

Code: H6132-10MG D2-231

Application

DL-3-Hydroxy-3-methylglutaryl coenzyme A sodium salt hydrate has been used in drug treatment to study its effect on mTORC1 regulation. It has also been used to co...


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Your Price
€420.29 10MG
€516.96 inc. VAT

Application

DL-3-Hydroxy-3-methylglutaryl coenzyme A sodium salt hydrate has been used in drug treatment to study its effect on mTORC1 regulation. It has also been used to compare the acylomes of two reactive acyl-CoA species, like HMG-CoA andglutaryl-CoA.

Biochem/physiol Actions

DL-3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) is a substrate used to study the specificity and kinetics of the enzyme 3-hydroxyl-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase. HMG-CoA is the key intermediate in the biosynthsis of terpenes and ketone bodies. Its metabolism is the target of statin drugs used to control cholesterol levels.

DL-3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA)acts as a precursor of cholesterol synthesis. Inhibition of HMG-CoA can decrease cholesterol synthesis. This can be converted to β-hydroxybutyrate in the blood. HMG-CoA is a regulatory enzyme for cholesterol biosynthesis, it couples with LDL receptor to regulate cholesterol synthesis, once it is inhibited it would decrease cholesterol synthesis.

General description

DL-3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA)is obtained from acetyl-CoAandacetoacetyl-CoA during condensation with the help of HMG-CoA synthase.

Packaging

10, 25 mg in poly bottle

5 mg in glass bottle

assay≥90% (HPLC)
InChI keyQGWMCHPRNDWWMT-UAUHQYJPSA-L
InChI1S/C27H44N7O20P3S.2Na.H2O/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34;;;/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45);;;1H2/q;2*+1;/p-2/t14-,19-,20-,21-,25-,27?;;;/m1.../s1
Quality Level200
SMILES stringO.[Na+].[Na+].CC(O)(CC(O)=O)CC(=O)SCCNC(=O)CCNC(=O)[C@@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP([O-])([O-])=O)n2cnc3c(N)ncnc23
storage temp.−20°C
Code
Description
Unit Size
List Price
Qty
H6132-25MG
Unit:25MG
List Price: €853.01
Source:List Price
ADD
H6132-5MG
Unit:5MG
List Price: €391.31
Source:List Price
ADD
Cas Number103476-21-7
This product has met the following criteria: