Application

Harmane was used in trace level determination of harmane by planar chromatography coupled with (tandem) mass spectrometry. It was used to study interactions of norharman and harman with DNA.It may be used as matrix for analysis of cyclodextrins and for sulfated oligosaccharides in combination with DHB as co-matrix.

Biochem/physiol Actions

I₁ imidazoline binding site agonist.

General description

Harmane is a potent tremor-producing β-carboline alkaloid and neurotoxin.It is major representative of heterocyclic aromatic amines, a group of mutagenic and carcinogenic substances which are formed in meat from the precursors creatine, creatinine, amino acids and sugars during the heating at high temperatures.Blood harmane concentration is elevated in essential tremor, late-life neurological disease.

Packaging

1 g in glass bottle

Preparation Note

Harmane dissolves in methanol at a concentration of 50mg/ml to form a clear, colourless to yellow solution.