6-Chloropurine, 99%

Application

6-Chloropurine may be used: To prepare purine via catalytic dehydrogenation. To prepare 9-alkylated adenines via Mitsunobu reaction with various alcohols.As a starting material to synthesize dihydroisoxazole 6-chloropurine.

General description

6-Chloropurine (6-CIPH), a 6-substituted purine derivative, is an antileukemic drug. It can be prepared by the chlorination of hypoxanthine with phosphorus oxychloride in the presence of dimethylaniline. The NMR-based conformational analysis of the products formed during the reaction of 6-CIPH with 3,4-di-O-acetyl-D-xylal and 3,4-di-O-acetyl-L-arabinal have been reported. 6-CIPH can undergo palladium-catalyzed cross coupling with organostannanes at 6-position to form the corresponding arylated or alkylated products.

Packaging

5 g in glass bottle