Application

Analytes: EGF, FABP1, IP-10, KIM-1, Osteopontin (OPN), PTH, Renin Recommended Sample type: serum and plasma Recommended Sample dilution: 1:2 in kit Assay Buffer. Customers need to determine the optimal dilution factor for their samples. Our recommendations are on serum and plasma samples from normal subjects. Assay Run Time: Overnight Research Category: Toxicity

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

Design your multiplex kit by choosing available analytes within this panel.

General description

Maintenance of physiological balance in the body is attributed in part to normal kidney function. Altered kidney function due to injury, drug toxicity or kidney failure may be life threatening. Toxicity is the leading cause of drug failure, so research is expanding in search of more sensitive, rapid methods to determine organ-specific damage as quickly as possible. Traditionally, blood urea nitrogen (BUN) and serum creatinine tests have been used to determine drug-induced damage to the kidney. These tests only detect kidney damage after it begins and do not allow for the elucidation of where in the kidney the damage has occurred. Specificity and earlier detection of kidney injury is vital, and this area of research is expanding in search of more sensitive, rapid methods for determining the specific area of damage in kidney. The MILLIPLEX^® portfolio provides valuable research assays to investigate multiple biomarkers of kidney injury in human serum and plasma samples using the Luminex^® xMAP^® instrument platform. The MILLIPLEX^® Human Kidney Injury Bead Panel 4 contains all the components necessary to measure the following seven biomarkers in any combination using Luminex^® xMAP^® technology: EGF, FABP1, IP-10, KIM-1, Osteopontin (OPN), PTH and Renin. The kit uses a 96-well format, contains a lyophilized standard cocktail, two quality controls and can measure up to 38 serum or plasma samples in duplicate. Panel Type: Toxicity

Legal Information

xMAP is a registered trademark of Luminex Corp

Luminex is a registered trademark of Luminex Corp

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Sensitivity: Please see kit protocol for individual assay sensitivities.

Please contact Technical Service for linearity of dilution.

Packaging

Everything you need in a single kit.

Specificity

Cross ReactivtyThere was no or negligible cross-reactivity between the antibodies for an analyte and any of the other analytes within a panel.

Storage and Stability

Recommended storage for kit components is 2 - 8°C.