Application

Used to detect/quantify: GLP-2

This assay requires 50 µl of rat or human samples and is performed at room temperature as a 4 hour assay. GLP-2 has also been detected in guinea pig, horse, porcine, and non-human primate samples.

Research CategoryMetabolism

Research Sub CategoryOsteoporosis

Disclaimer

For research use only. Not for use in diagnostic procedures.

General description

The glucagon-like peptides GLP-1 and GLP-2 are important gut hormones released from the small intestine upon nutrient ingestion. In circulation, GLP-2 is present in two molecular forms, GLP-2 (1-33) and GLP-2 (3-33). Similar to GLP-1, active form GLP-2 (1-33) is cleaved to inactive form GLP-2 (3-33) by protease DPPIV. GLP-2 has been shown to play important roles in the regulation of gastrointestinal functions (digestion, absorption, motility, epithelial growth, and blood flow) and bone resorption. Thus, GLP-2 or its analogs may have therapeutic potentials for the treatment of diseases such as Crohn's disease and osteoporosis.

Other Notes

Please contact Technical Service for linearity of dilution.

Specificity

Human GLP-2 1-33 100%
Human GLP-2 3-33 112%
Rat GLP-2 101%