1-(Trimethylsilyl)imidazole - Pyridine mixture, for GC derivatization

Application

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General description

1-(Trimethylsilyl)imidazole-Pyridine mixture is useful for derivatizing wet sugar samples, hindered hydroxyl groups in steroids and, in conjunction with fluorinated acylation reagents, amino acids. For moderately hindered or slowly reacting compounds, pyridine is an especially useful solvent for TMSI because of its ability to act as an HCl acceptor in silylation reactions involving organochlorosilanes.

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Silylating mixture for the mild silylation of alcohols. It is often called Tri-Sil Z