(2S,5S)-(-)-2-tert-Butyl-3-methyl-5-benzyl-4-imidazolidinone, 97%

Code: 663107-500MG D2-231

Application

Metal-free OrganoCatalyst technology for asymmetric catalysis. Catalyzes asymmetric indole alkylations, Friedel-Crafts alkylations, and a broad range of conjugate...


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Your Price
€147.00 500MG
€180.81 inc. VAT

Application

Metal-free OrganoCatalyst technology for asymmetric catalysis. Catalyzes asymmetric indole alkylations, Friedel-Crafts alkylations, and a broad range of conjugate addition reactions in high enantiomeric excess.

(2S,5S)-(-)-2-tert-Butyl-3-methyl-5-benzyl-4-imidazolidinone is a second-generation MacMillan catalyst, which can be used as a chiral organocatalyst in: The chiral transformation reaction, including Friedel-Crafts and Mukaiyama-Michael reactions. The preparation of substituted spiroundecenetriones via asymmetric domino Knoevenagel/Diels-Alder reactions. The asymmetric synthesis of β-hydroxy aldehydes and their dimethylacetals via aldehyde-aldehyde aldol condensation reaction. The enantioselective α-fluorination of aldehydes using N-fluorobenzenesulfonamide as a fluorinating agent. The stereoselective preparation of (oxomethyl)oxabicyclo[3.2.1]octenones and tricyclic pyrroles via [4+3] cycloaddition of (trialkylsiloxy)pentadienals to furans.

Features and Benefits

Advantages of MacMillan imidazolidinone organocatalysts:Superior enantiocontrol in numerous transformationsHigh activities at low catalyst loadingsExtraordinary functional group tolerance

General description

(2S,5S)-(-)-2-tert-Butyl-3-methyl-5-benzyl-4-imidazolidinone is a chiral imidazolidinone organocatalyst, developed by MacMillan and co-workers.

Legal Information

U.S. Pat. 6,369,243 and related patents apply. For research purposes only.

Packaging

1 g in glass bottle

500 mg in glass insert

assay97%
formsolid
InChI keySKHPYKHVYFTIOI-JSGCOSHPSA-N
InChI1S/C15H22N2O/c1-15(2,3)14-16-12(13(18)17(14)4)10-11-8-6-5-7-9-11/h5-9,12,14,16H,10H2,1-4H3/t12-,14-/m0/s1
mp93-100 °C (lit.)
Quality Level100
SMILES stringCN1[C@H](N[C@@H](Cc2ccccc2)C1=O)C(C)(C)C
Cas Number346440-54-8
This product has met the following criteria to qualify for the following awards:



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