Alkyne-PEG4-maleimide, 90% (HPLC)

Code: 764205-10MG D2-231

Application

Heterobifunctional crosslinker enabling the connection of an azide containing compound or biomolecule to one with a thiol. The maleimide group will react preferen...


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Your Price
€73.50 10MG
€90.41 inc. VAT

Application

Heterobifunctional crosslinker enabling the connection of an azide containing compound or biomolecule to one with a thiol. The maleimide group will react preferentially with thiols to form a covalent adduct and the terminal alkyne will react with azides via copper-catalyzed 1,3-dipolar cycloaddition click chemistry. The hydrophilic PEG spacer adds to the water solubility of this reagent, allowing for easy modification cysteine containing biomolecules such as antibodies, proteins and peptides with the terminal alkyne. The PEG spacer also reduces aggregation of modified proteins stored in solution by adding hydrophilic character.

Alkyne-PEG4-maleimide has been used for modification of Csy containing bacterial collagens by introducing alkyne moiety to enable it for further chemical modification.

Packaging

10, 25 mg in amber glass bottle

assay90% (HPLC)
formliquid
InChI keyGHEBECZRHJXPTL-UHFFFAOYSA-N
InChI1S/C18H26N2O7/c1-2-8-24-10-12-26-14-15-27-13-11-25-9-6-19-16(21)5-7-20-17(22)3-4-18(20)23/h1,3-4H,5-15H2,(H,19,21)
mp62-67 °C
Quality Level100
reaction suitabilityreaction type: click chemistry, reagent type: cross-linking reagent
SMILES stringO=C(N1CCC(NCCOCCOCCOCCOCC#C)=O)C=CC1=O
storage temp.−20°C
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