Complement factor H from human plasma, 1 mg/mL in PBS, pH 7.2, >=90% (SDS-PAGE)

Code: C5813-.1MG D2-231

Application

Complement factor H (CFH) is a plasma regulator of the complement protein C3b in the alternative pathway of the complement system. Research has shown that binding...


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Application

Complement factor H (CFH) is a plasma regulator of the complement protein C3b in the alternative pathway of the complement system. Research has shown that binding of CFH is important for pathogenesis of group A streptococcus (GAS), and inhibition of this binding may be an effective management of GAS infections.

Biochem/physiol Actions

C3b-binding protein which regulates the formation and function of complement C3 and C5 convertases.

Complement factor H plays an essential role in the homeostasis of the complement system and in preventing collateral damage to bystander cells and tissues by complement activation.

Other Notes

View more information on the complement pathway at www.sigma-aldrich.com/enzymeexplorer

assay≥90% (SDS-PAGE)
biological sourcehuman plasma
concentration1 mg/mL in PBS, pH 7.2
formliquid
Gene Informationhuman ... CFH(3075)
Quality Level200
shipped indry ice
storage temp.−70°C
technique(s)activity assay: suitable
UniProt accession no.P08603
Cas Number80295-65-4
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