Analysis Note

C6 is depleted by immunoadsorption as judged by a highly sensitive hemolytic assay.

Application

Complement C6 is one of the end terminals of the complement system contained in the membrane attack complex (MAC). A deficiency of C6 may result in an increased susceptibility to Neisseria meningitidis. Research has identified that a mutation which leads to a 31 bp deletion in exon 10 in the C6 gene results in C6 deficiency. A coagulation defect has also been observed in mice that are C6 deficient.

Physical form

Supplied as a solution in PBS, pH 7.4