Demeclocycline hydrochloride, >=90% (HPLC), powder

Code: D6140-1G D2-231

Biochem/physiol Actions

Used to study mechanisms of bacterial protein synthesis inhibition at the level of the 30S subunit and aminoacy-tRNA A-site binding.

Because it ...


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Biochem/physiol Actions

Used to study mechanisms of bacterial protein synthesis inhibition at the level of the 30S subunit and aminoacy-tRNA A-site binding.

Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.

Demeclocycline hydrochloride is a tetracycline antibiotic derived from a strain of Streptomyces aureofaciens. DMC protects neurons from glutamate induced toxicity by suppressing calpain I and II activities.

General description

Chemical structure: tetracycline

antibiotic activity spectrumGram-positive bacteria, Gram-negative bacteria
assay≥92% (HPLC)
formpowder or crystals
InChI keyGVSJQNRGSCOSNJ-KBHRXELFSA-N
InChI1S/C21H21ClN2O8.ClH/c1-24(2)14-7-5-6-10(16(27)12-9(25)4-3-8(22)11(12)15(6)26)18(29)21(7,32)19(30)13(17(14)28)20(23)31;/h3-4,6-7,14-15,25-26,28-29,32H,5H2,1-2H3,(H2,23,31);1H/t6-,7-,14-,15-,21-;/m0./s1
mode of actionprotein synthesis | interferes
Quality Level200
SMILES stringCl[H].[H][C@]12C[C@@]3([H])[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C(=O)c4c(O)ccc(Cl)c4[C@H]2O
solubilitysoluble (1 mg/mL of Demeclocycline Hydrochloride in 0.01 N hydrochloric acid)
storage temp.−20°C
technique(s)cell culture | mammalian: suitable
Cas Number64-73-3
Pack1G
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