Analysis Note

The proliferative activity of human IL-1α is tested in culture using the murine cell line D10S.

Application

Interleukin-1α (IL-1α) has been used:to study its effects on human colorectal adenocarcinoma cellsto stimulate primary human fetal retinal pigment epithelium (hfRPE) cellsto pre-stimulate human THP-1 monocytes

Biochem/physiol Actions

Interleukin-1α (IL-1α) plays a crucial role in inflammation during cell necrosis. It also regulates the recruitment of interleukin-1β (IL-1β), neutrophils, chemokines, and other cytokines at the site of injury. IL-1α exhibits a dual function of binding to its cell surface receptor as well as chromatin.

General description

Interleukin-1α (IL-1α) is a cytokine that belongs to the interleukin-1 (IL-1) family. It is located intracellularly in hematopoieticand non-hematopoietic cells. IL-1α gene is located on the human chromosome at 2q14.1.

Packaging

2 µg in serum bottle

Physical form

Lyophilized from 0.2 µm filtered 10 mM sodium phosphate , pH 8.0, plus 50 mm NaCl and 50 µg bovine serum albumin (BSA) per µg cytokine.