Application

Polymer with cell adhesion motif (RGD) employed to generate cell-adhesive hydrogel

Components

TRUERGD contains RGD degradable polymer lyophilized and water

Features and Benefits

Contains cell adhesion motif RGD (Acetyl-Cys-Doa*-Doa-Gly-Arg-Gly-Asp-Ser-Pro-NH2), which binds to appropriate integrin receptors on cells.*Doa : 8-amino-3,6-dioxaoctanoic acid

General description

RGD sequences on extracellular matrix proteins (fibronectin, vitronectin) promote cell adhesion to cellular integrin receptors. The thiol group on the N-terminus of TrueGel3D^® RGD peptide acts as linker to bind RGD motif to the polymer (Dextran/PVA). The conjugated RGD motif on polymer promotes adhesion of cells with appropriate integrin receptors.

TrueGel3D^® is a commercially available polymer-based diverse array of scaffolds for 3D in vitro tumor models. The RGD peptide present in these hydrogels enable cell attachment.

Legal Information

TRUEGEL3D is a registered trademark of Merck KGaA, Darmstadt, Germany