Application
2,2-Dimethyl-1,3-dioxane-4,6-dione was used in the synthesis of:macrocyclic β-keto lactone4-pyridyl-substituted heterocycles2-substituted indolesisofraxidin.
General description
2,2-Dimethyl-1,3-dioxane-4,6-dione (Meldrum′s acid) is widely used in organic synthesis, especially for multiple C-C bond formations due to its adequate acidity (pKa 4.83) and steric rigidity. Knoevenagel condensation reaction between aldehydes and Meldrum′s acid are accelerated in ionic liquids.
Packaging
10, 25, 100 g in glass bottle
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