Application

Reactant for: Silver-mediated C-H trifluoromethylation of arenes Preparation of trifluoromethyl ketone analog of L-arginine having contrasting inhibitory activity against human arginase I and histone deacetylase 8 Organocatalyzed regio- and enantioselective allylic trifluoromethylation of Morita-Baylis-Hillman adducts Palladium-catalyzed oxidative trifluoromethylation of indoles Preparation of 5-HT1A antagonists Used as difluorocarbene source

TMSCF₃ can be used as a reagent for:Conversion of aromatic aldehydes to difluoromethylated products.C-H trifluoromethylation of arenes, terminal alkynes, tertiary amines, heteroarenes, allylic, and terminal alkenes using metal catalyst or metal free oxidative trifluoromethylation reaction.It can also be used in trifluoromethylation of: Non-activated aldimines.Heterocumulenes.Azomethine imines.

General description

Trimethyl(trifluoromethyl)silane (TMSCF₃) is also called as Ruppert-Prakash fluorination reagent. It is extensively used for the synthesis of trifluoromethyl-containing compounds.

Packaging

10, 50 mL in glass bottle