Rifamycin SV sodium salt, potency: >=900 units (dry basis)

Application

Rifamycin SV is a broad-spectrum semisynthetic antimicrobial agent of the rifamycin group. It is used to study potential genes, such as rif15 and rif16, which may be involved in the conversion of rifamycin SV into rifamycin B. It is a potential treatment for traveler’;s diarrhea (TD), Clostridium difficile-associated disease (CDAD) and rheumatoid knee synovitis. It is used in electron spin resonance studies.

Biochem/physiol Actions

Rifamycin SV inhibits selective (E. coli, B. subtilis) bacterial DNA-dependent RNA polymerase by binding to the polymerase β-subunit, a mechanism similar to rifabutin. It acts as a selective cytochrome P450 3A4 inducer. It has limited oral absorption that is active against Gram-positive bacteria and is moderately active against Gram-negative organisms.

General description

Chemical structure: macrolide

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Light sensitive. Air sensitive. Store under inert gas

Packaging

1g,5g