Lincomycin hydrochloride, >=90% (TLC)

Code: L6004-1MU D2-231

Application

Lincomycin hydrochloride is an antibiotic used to study the inhibition of protein synthesis, bacterial antibiotic resistance, and protein and surfactant binding ...


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Application

Lincomycin hydrochloride is an antibiotic used to study the inhibition of protein synthesis, bacterial antibiotic resistance, and protein and surfactant binding It is produced by Streptomyces lincolnensis var. lincolnensis and has been used in the treatment of Staphylococcal, Streptococcal, and Bacteroides fragilis infections.

Biochem/physiol Actions

Mode of action: Lincomycin inhibits bacterial protein synthesis by forming cross-links within the peptidyl transferase loop region of the 23S rRNA.† Antimicrobial spectrum: Lincomycin hydrochloride is effective against gram-positive bacteria.

General description

Chemical structure: macrolide

Packaging

1000000, 5000000, 25000000 units in glass bottle

Preparation Note

This product is soluble in water at 50 mg/mL, yielding a clear, colorless solution.

antibiotic activity spectrumGram-positive bacteria
assay≥90% (TLC)
colorwhite to faint yellow
InChI keyPOUMFISTNHIPTI-BOMBIWCESA-N
InChI1S/C18H34N2O6S.ClH/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25);1H/t9-,10-,11+,12-,13+,14-,15-,16-,18-;/m1./s1
mode of actionprotein synthesis | interferes
potency800-900 units per mg
Quality Level200
SMILES stringCl.CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@H]([C@@H](C)O)[C@H]2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O
solubilityH2O: soluble 50 mg/mL
storage temp.2-8°C
Cas Number859-18-7
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