S-(5-Adenosyl)-L-methionine iodide,;, from yeast, >=80% (HPLC), >=80% (spectrophotometric assay)

Analysis Note

Purity based on UV and HPLC.

Application

S-(5′-Adenosyl)-L-methionine (SAM, AdoMet) is used as a primary methyl donor molecule in mammalian cell culture and the first step metabolite in methionine biosynthesis.

Biochem/physiol Actions

Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.

Caution

This material is very unstable at room temperature.

Packaging

5, 25, 100 mg in glass bottle