Vinblastine sulfate salt, powder, >=96% (HPLC)

Code: V1377-1MG D2-231

Application

Vinblastine sulfate salt has been used:as a microtubule depolymerizing drug for the synchronization of human cell lines in G2/M phaseas a multidrug resistance scr...


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Application

Vinblastine sulfate salt has been used:as a microtubule depolymerizing drug for the synchronization of human cell lines in G2/M phaseas a multidrug resistance screening substrate in human colon cancer cell line (HCT116) cell lineas an antimicrotubule agent in sub perineural glia of Drosophila brain

Biochem/physiol Actions

Plant alkaloid that inhibits microtubule assembly by binding tubulin and inducing self-association in spiral aggregates in a reaction that appears to be regulated by the C-terminus of β-tubulin and is enhanced by GDP and GTP. Depolymerizes microtubules. Arrests the cell cycle in G2/M-phase by blocking mitotic spindle formation. Triggers Raf-1 activation, phosphorylation of bcl-2-family proteins, induction of p53 expression, and apoptosis in several tumor cell lines. Substrate of Pgp and CYP3A4.

Features and Benefits

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

absorption16.2 at 259 nm in ethanol at 1 mM, 53.7 at 214 nm in ethanol at 1 mM, 14 at 270 nm in 0.1 M phosphate buffer at 1 mM
antibiotic activity spectrumneoplastics
assay≥97% (HPLC)
colorwhite to light yellow
form(powder or amorphous or crystalline powder)
Gene Informationhuman ... TBCC(6903), TUBA1A(7846), TUBA1B(10376), TUBA1C(84790), TUBA3C(7278), TUBA3E(112714), TUBA4A(7277), TUBB(203068), TUBB1(81027), TUBB2A(7280), TUBB2B(347733), TUBB3(10381), TUBB4A(10382), TUBB4B(10383), TUBB6(84617), TUBB8(347688)
InChI keyKDQAABAKXDWYSZ-PNYVAJAMSA-N
InChI1S/C46H58N4O9.H2O4S/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7;1-5(2,3)4/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3;(H2,1,2,3,4)/t28-,37-,38+,39+,42-,43+,44+,45-,46-;/m0./s1
mode of actionDNA synthesis | interferes
mp267 °C (dec.) (lit.)
originatorEli Lilly
Quality Level200
SMILES stringOS(O)(=O)=O.[H][C@@]12CN(CCc3c([nH]c4ccccc34)[C@@](C1)(C(=O)OC)c5cc6c(cc5OC)N(C)[C@@]7([H])[C@](O)([C@H](OC(C)=O)[C@]8(CC)C=CCN9CC[C@]67[C@]89[H])C(=O)OC)C[C@](O)(CC)C2
storage temp.2-8°C
Cas Number143-67-9
This product has met the following criteria to qualify for the following awards:



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