Valinomycin,;, >=98% (TLC), >=90% (HPLC), solid

Code: V0627-100MG D2-231

Application

Valinomycin has been used: to equilibrate intracellular pH and extracellular pH of 5 (and 6-)-carboxyfluorescein succinimidyl ester (cFSE) in Escherichia coli...


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€359.30 100MG
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Application

Valinomycin has been used: to equilibrate intracellular pH and extracellular pH of 5 (and 6-)-carboxyfluorescein succinimidyl ester (cFSE) in Escherichia coli strain B23as an ionophore to equilibrate intracellular pH and extracellular pH of lactic acid bacteria (LAB) strainsto establish the desired pH for acid-base transition and formation of K+-valinomycin diffusion potential

Biochem/physiol Actions

K+-selective ionophoric cyclodepsipeptide; potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and antagonizes ET-induced vasoconstriction.

Valinomycin selectively transfers alkali metal ions via biological and synthetic membranes. The formation of a metal ion-peptide complex contributes to this ion-transporting. Valinomycin can create stable complexes with potassium, rubidium, and cesium (K+, Rb+, and Cs+) .

General description

Chemical structure: peptide

Valinomycin is a cyclic peptide, which contains d-valine,d-α-hydroxyvaleric acid,l-valine, andl-lactic acid in the sequential order of cyclo-[(l-Val-d-Hyv-d-Val-l-Lac)3].

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Packaging

10MG,25MG,100MG,500MG

antibiotic activity spectrumparasites, Gram-positive bacteria, viruses
assay≥90% (HPLC), ≥98% (TLC)
colorwhite
formpowder
InChI keyFCFNRCROJUBPLU-RPUZOQEISA-N
InChI1S/C54H90N6O18/c1-22(2)34-49(67)73-31(19)43(61)55-38(26(9)10)53(71)77-41(29(15)16)47(65)59-36(24(5)6)51(69)75-33(21)45(63)57-39(27(11)12)54(72)78-42(30(17)18)48(66)60-35(23(3)4)50(68)74-32(20)44(62)56-37(25(7)8)52(70)76-40(28(13)14)46(64)58-34/h22-42H,1-21H3,(H,55,61)(H,56,62)(H,57,63)(H,58,64)(H,59,65)(H,60,66)/t31-,32-,33-,34-,35+,36+,37-,38-,39-,40+,41+,42+/m0/s1
mode of actioncell membrane | interferes
Quality Level300
SMILES stringCC(C)[C@@H]1NC(=O)[C@H](C)OC(=O)[C@@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC1=O)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C
solubilityDMSO: ≥50 mg/mL, H2O: insoluble
storage condition(Keep container tightly closed in a dry and well-ventilated place.)
storage temp.2-8°C
Cas Number2001-95-8
Hazard Class6.1
Un Number2811
Pack GroupI
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