TRAM-34, >=98% (HPLC), solid

Application

TRAM-34 has been used to study its effect on the prevention of vascular restenosis after balloon angioplasty.

Biochem/physiol Actions

TRAM-34 is a potent inhibitor of the intermediate-conductance Ca²⁺-activated K⁺ channel.

TRAM-34 exhibits 100-fold selectivity (K_d = 20 nM) for IK_Ca1 channels over other K⁺ channels (Charybdotoxin, K_d = 5 nM, Clotrimazole, K_d = 70 nM; Nitrendipine K_d = 900 nM). Furthermore, TRAM-34 is known to suppress the activation of human T lymphocytes,.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

5, 25 mg in glass bottle

Preparation Note

TRAM-34 is soluble in DMSO at 2 mg/ml. However, it is insoluble in water.