THI,

Code: T6330-1MG D2-231

Biochem/physiol Actions

2-Acetyl-4-tetrahydroxybutyl imidazole (THI) is known to induce peripheral blood lymphopenia in rats. Studies in rats have also reported that THI can ...


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Biochem/physiol Actions

2-Acetyl-4-tetrahydroxybutyl imidazole (THI) is known to induce peripheral blood lymphopenia in rats. Studies in rats have also reported that THI can affect lymphocyte migration and degradation.

THI is an inhibitor of sphingosine-1-phosphate lyase and acts as an immunosuppressant. Sphingosine-1-phosphate (S1P) lyase catalyzes the irreversible decomposition of S1P to hexadecanaldehyde and phosphoethanolamine. Reducing S1P lyase activity results in therapeutic levels of immunosuppression without the non-lymphoid lesions that result from synthetic S1P receptor agonists.

Packaging

1, 5, 25 mg in glass bottle

Preparation Note

THI is soluble in DMSO at a concentration that is greater than 5 mg/ml.

colorwhite to light brown
formpowder
InChI keyCQSIXFHVGKMLGQ-BWZBUEFSSA-N
InChI1S/C9H14N2O5/c1-4(13)9-10-2-5(11-9)7(15)8(16)6(14)3-12/h2,6-8,12,14-16H,3H2,1H3,(H,10,11)/t6-,7-,8-/m1/s1
Quality Level100
SMILES stringCC(=O)c1nc(c[nH]1)[C@@H](O)[C@H](O)[C@H](O)CO
solubilityDMSO: 2 mg/mL, clear (warmed)
storage temp.2-8°C
Cas Number94944-70-4
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