Tyrphostin AG 825, >=92.5%

Code: T5443-2MG D2-231

Application

Tyrphostin AG 825 has been used to study its effects on iodide uptake in EMT6 cells1.

Biochem/physiol Actions

Tyrphostin A...


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€112.84 2MG
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Application

Tyrphostin AG 825 has been used to study its effects on iodide uptake in EMT6 cells1.

Biochem/physiol Actions

Tyrphostin AG 825 has been used in combination with hypericin-mediated photodynamic therapy (HY-PDT) for evaluating its therapeutic effects in HER2 overexpressing human breast cancer cells. This study reported that AG 825 combination increased the induction of cell death, HER2 degradation and inhibited colony formation in cancer cells2.

EGF receptor tyrosine kinase inhibitor, inactive against IGF-1 Receptor.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Preparation Note

Tyrphostin AG 825 is soluble in DMSO and methanol.

assay≥92.5%
formpowder
InChI keyKXDONFLNGBQLTN-WUXMJOGZSA-N
InChI1S/C19H15N3O3S2/c1-25-15-8-11(6-12(9-20)18(21)24)7-13(17(15)23)10-26-19-22-14-4-2-3-5-16(14)27-19/h2-8,23H,10H2,1H3,(H2,21,24)/b12-6+
Quality Level200
SMILES stringCOc1cc(cc(CSc2nc3ccccc3s2)c1O)C=C(/C#N)C(N)=O
solubilitymethanol: soluble, DMSO: soluble
storage temp.−20°C
Cas Number149092-50-2
This product has met the following criteria to qualify for the following awards:



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