Triparanol, >=97% (HPLC), powder

Code: T5200-5MG D2-231

Application

Triparanol has been used to inhibit cholesterol biosynthesis in lipid rafts1. Triparanol has also been used as a 3β-hydroxysterol-Δ24-reduct...


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€214.29 5MG
€263.58 inc. VAT
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Application

Triparanol has been used to inhibit cholesterol biosynthesis in lipid rafts1. Triparanol has also been used as a 3β-hydroxysterol-Δ24-reductase inhibitor to study its effect on delayed-rectifier potassium current (Iks) channels2.

Biochem/physiol Actions

Desmosterol Delta24 (D24) reductase inhibitor.

Triparanol is known to repress Hedgehog signaling in cancer cells and can also inhibit tumor growth3.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. T5200.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Packaging

5, 25 mg in glass bottle

Preparation Note

Triparanol is soluble in DMSO at 20 mg/ml and is also soluble in alcohol. It is slightly soluble in olive oil and is insoluble in water.

assay≥97% (HPLC)
colorwhite to off-white
formpowder
Gene Informationhuman ... DHCR24(1718), EBP(10682)
InChI keySYHDSBBKRLVLFF-UHFFFAOYSA-N
InChI1S/C27H32ClNO2/c1-4-29(5-2)18-19-31-26-16-12-24(13-17-26)27(30,23-10-6-21(3)7-11-23)20-22-8-14-25(28)15-9-22/h6-17,30H,4-5,18-20H2,1-3H3
mp102.9-103.7 °C
Quality Level100
SMILES stringCCN(CC)CCOc1ccc(cc1)C(O)(Cc2ccc(Cl)cc2)c3ccc(C)cc3
solubilityolive oil: slightly soluble, alcohol: soluble, DMSO: 20 mg/mL, H2O: insoluble
storage temp.2-8°C
Cas Number78-41-1
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