Topotecan hydrochloride hydrate, >=98% (HPLC and enzymatic)

Code: T2705-10MG D2-231

Application

Topotecan has been used as a positive control for the identification and analysis of HIF-1α and VEGF inhibitors in human glioma cells under hypoxic condition...


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€88.80 10MG
€109.22 inc. VAT
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Application

Topotecan has been used as a positive control for the identification and analysis of HIF-1α and VEGF inhibitors in human glioma cells under hypoxic conditions1. It has also been used for in vitro apoptosis assays in PA317 cells2.

Biochem/physiol Actions

Topotecan is a topoisomerase I inhibitor and an apoptosis inducer. It is a potent antineoplastic agent.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

This compound is a featured product for ADME Tox and Apoptosis research. Discover more featured ADME Tox and Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Packaging

10, 50 mg in glass bottle

Preparation Note

Topotecan hydrochloride hydrate is soluble in DMSO at a concentration that is greater than or equal to 20 mg/ml.

assay≥98% (HPLC and enzymatic)
coloryellow
formpowder
Gene Informationhuman ... TOP1MT(116447)
InChI keyUCFGDBYHRUNTLO-QHCPKHFHSA-N
InChI1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1
originatorGlaxoSmithKline
Quality Level100
solubilityDMSO: ≥20 mg/mL
storage conditiondesiccated, protect from light
storage temp.−20°C
Cas Number123948-87-8
This product has met the following criteria to qualify for the following awards:



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