Application
Lopinavir has been used as a ZMPSTE24 and human immunodeficiency virus protease inhibitor.
Biochem/physiol Actions
Lopinavir is an antiviral HIV Protease Inhibitor. Lopinavir has insufficient bioavailability alone, so it is used in therapy in combination with Ritonavir, a HIV protease inhibitor, which inhibits cytochrome P450-3A4 (CYP3A4), a liver enzyme that normally metabolizes protease inhibitors. Lopinavir also has an ability to inhibit ZMPSTE24 (zinc metallopeptidase STE24).
This product has met the following criteria to qualify for the following awards: