ESI-09, >=98% (HPLC)

Code: SML0814-5MG D2-231

Application

ESI-09 has been used as an antagonist for exchange factor directly activated by cAMP (EPAC).

Biochem/physiol Actions

ESI-09 is a pote...


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€166.70 5MG
€205.04 inc. VAT
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Application

ESI-09 has been used as an antagonist for exchange factor directly activated by cAMP (EPAC).

Biochem/physiol Actions

ESI-09 is a potent, specific inhibitor of EPAC (exchange protein directly activated by cAMP). ESI-09 inhibits EPAC1 and EPAC2 with IC50 values of 3.2 and 1.4 µM, respectively, with no activity against PKA at 25 µM. In pancreatic cell lines, the compound blocks phosphorylation of Akt and insulin secretion. ESI-09 inhibits migration of pancreatic cancer cell lines.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
color, faint yellow to dark orange
formpowder
Quality Level100
solubilityDMSO: 20 mg/mL, clear
storage temp.2-8°C
Cas Number263707-16-0
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