Methazolamide, >=98% (HPLC)

Code: SML0720-50MG D2-231

Biochem/physiol Actions

Methazolamide has a plasma half-life of 14 hours in humans. Methazolamide has relatively good lipid solubility and low plasma protein binding ability....


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Biochem/physiol Actions

Methazolamide has a plasma half-life of 14 hours in humans. Methazolamide has relatively good lipid solubility and low plasma protein binding ability. Thus, it diffuses into tissues and fluids much more readily than acetazolamide, another carbonic anhydrase inhibitor. Methazolamide has less side effects than acetazolamide.

Methazolamide is a cell-permeable and potent carbonic anhydrase (CA) inhibitor that is used in the treatment of glaucoma. Methazolamide is an insulin sensitizer that reduces hepatic glucose generation in animal models.

Other Notes

Light sensitive

Packaging

50 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
Gene Informationhuman ... CA1(759), CA2(760), CA4(762), CA7(766)
InChI keyFLOSMHQXBMRNHR-QPJJXVBHSA-N
InChI1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12)/b7-4+
mp208 °C (dec.) (lit.)
Quality Level100
SMILES stringCN1N=C(SC1=NC(C)=O)S(N)(=O)=O
solubilityDMSO: 20 mg/mL, clear
storage conditionprotect from light
storage temp.2-8°C
Cas Number554-57-4
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