Application

SF1670 has been used:To study the effect of microRNA-30a on PTEN (phosphatase and tensin homologue deleted on chromosome 10 ) expression regulation.To study the formation of autophagosomes, induced by EGF (Epidermal growth factor) - dependent PTEN expression.To study the role of PTEN in the regulation of autophagy induction in human normal endometrial stromal cells.

Biochem/physiol Actions

SF1670 is a selective PTEN (phosphatase and tensin homolog) inhibitor with an IC₅₀ of 2 micromolar. PTEN inhibition by SF1670 was shown to increase neutrophil activity (polarization, phagocytosis, oxidative burst, and recruitment to site of infection), thereby enhancing the inflammatory response and bacteria-killing capacity of neutopenic mice.

PTEN prevents PI3-K(phosphoinositide 3-kinase)/Akt signaling pathway, which is very essential for neuronal regeneration. Therefore, inhibition of PTEN by SF1670 may support neuronal regeneration.

Packaging

5, 25 mg in glass bottle