Deshydroxy LY-411575, >=98% (HPLC)

Code: SML0649-5MG D2-231

Application

Deshydroxy LY-411575 has been used in dibenzazepine (DBZ) treatment and chemical treatment.

Biochem/physiol Actions

LY411575 prevents...


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€134.60 5MG
€165.56 inc. VAT
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Application

Deshydroxy LY-411575 has been used in dibenzazepine (DBZ) treatment and chemical treatment.

Biochem/physiol Actions

LY411575 prevents SPP (signal peptide peptidase) dependent cleavage of HCV (hepatitis C virus) core protein.

Deshydroxy LY-411575 is a cell-permeable γ-secretase inhibitor and inhibtor of Notch processing. Deshydroxy LY-411575 significantly lowers both brain and plasma Aβ40 levels by ~72% in Tg2576 mutant APP transgenic mouse model and potently blocks Notch processing, with an IC50 of 1.7 nM in SupT1 cells.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
Quality Level100
solubilityDMSO: 15 mg/mL, clear
storage temp.−20°C
Cas Number209984-56-5
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