SB-590885, >=98% (HPLC)

Code: SML0501-5MG D2-231

Application

SB-590885 has been used as a component of a mixture to maintain naive human pluripotent stem cells (PSCs).It has also been used as B-Raf (BRAF) inhibitor to study...


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€166.70 5MG
€205.04 inc. VAT
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Application

SB-590885 has been used as a component of a mixture to maintain naive human pluripotent stem cells (PSCs).It has also been used as B-Raf (BRAF) inhibitor to study its effects on lung adenocarcinoma cell lines.

Biochem/physiol Actions

SB-590885 is a potent and selective ATP competitive inhibitor of B-Raf kinase with Kd = 300 pM for B-Raf, and >1000-fold selectivity over a panel of 22 commonly studied cellular kinases

Features and Benefits

This compound is featured on the MAPKKKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
InChI keyMLSAQOINCGAULQ-QLTSDVKISA-N
InChI1S/C27H27N5O2/c1-32(2)15-16-34-22-7-3-19(4-8-22)27-29-25(18-11-13-28-14-12-18)26(30-27)21-5-9-23-20(17-21)6-10-24(23)31-33/h3-5,7-9,11-14,17,33H,6,10,15-16H2,1-2H3,(H,29,30)/b31-24-
Quality Level100
SMILES stringCN(C)CCOc1ccc(cc1)-c2nc(-c3ccc4c(CCC4=NO)c3)c([nH]2)-c5ccncc5
solubilityDMSO: 2 mg/mL (clear solution, warmed)
storage temp.2-8°C
Cas Number405554-55-4
This product has met the following criteria to qualify for the following awards:



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