6,8-Bis(benzylthio)-octanoic acid, >=98% (HPLC)

Code: SML0404-5MG D2-231

Application

6,8-Bis(benzylthio)-octanoic acid has been used as pyruvate dehydrogenase (PDH) inhibitor:to study its effects on neurite outgrowth in primary mouse dorsal root g...


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€105.60 5MG
€129.89 inc. VAT
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Application

6,8-Bis(benzylthio)-octanoic acid has been used as pyruvate dehydrogenase (PDH) inhibitor:to study its effects on neurite outgrowth in primary mouse dorsal root ganglia cellsto induce α-smooth muscle actin (αSMA) and pro-collagen I expression and to assess PDH enzyme activity in whole-cell lysatesto validate basal respiration in tissue respirometry

Biochem/physiol Actions

6,8-Bis(benzylthio)-octanoic acid is an E1A pyruvate dehydrogenase (PDH) modulator that prevents cancer cells from metabolizing glucose for energy. 6,8-Bis(benzylthio)-octanoic acid has been granted orphan drug status by the US FDA for pancreatic cancer.

6,8-Bis(benzylthio)-octanoic acid (CPI-613) is a lipoate analog. It acts as a mitochondrial disrupter by blocking the mitochondrial enzymes pyruvate dehydrogenase and α-ketoglutarate dehydrogenase.

Other Notes

Air Sensitive

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
InChI keyZYRLHJIMTROTBO-UHFFFAOYSA-N
InChI1S/C22H28O2S2/c23-22(24)14-8-7-13-21(26-18-20-11-5-2-6-12-20)15-16-25-17-19-9-3-1-4-10-19/h1-6,9-12,21H,7-8,13-18H2,(H,23,24)
Quality Level100
SMILES stringOC(=O)CCCCC(CCSCc1ccccc1)SCc2ccccc2
solubilityDMSO: 15 mg/mL (clear solution)
storage temp.2-8°C
Cas Number95809-78-2
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