RAD51 Inhibitor B02, >=98% (HPLC)

Code: SML0364-5MG D2-231

Application

RAD51 Inhibitor B02 has been used:to test its effect on the polar body extrusion (PBE) rate in porcine oocytes for RAD51 inhibition in porcine embryos as RAD51 i...


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€176.00 5MG
€216.48 inc. VAT
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Application

RAD51 Inhibitor B02 has been used:to test its effect on the polar body extrusion (PBE) rate in porcine oocytes for RAD51 inhibition in porcine embryos as RAD51 inhibitor and to test its effect on targeted nucleotide substitution (TNS) in induced pluripotent stem cells (iPSCs)

Biochem/physiol Actions

B02 (3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone), a pyridinylvinyl-quinazolinone compound is cell-permeable. B02 inhibits human RAD51 recombinase and subsequent nucleofilaments formation. It halts homologous recombination (HR) repair events in cancer cells. B02 favors apoptosis in multiple myeloma and is crucial for sensitizing them to doxorubicin.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to dark brown
formpowder
InChI keyGEKDQXSPTHHANP-OUKQBFOZSA-N
InChI1S/C22H17N3O/c26-22-19-10-4-5-11-20(19)24-21(13-12-17-9-6-14-23-15-17)25(22)16-18-7-2-1-3-8-18/h1-15H,16H2/b13-12+
Quality Level100
SMILES stringO=C1N(CC2=CC=CC=C2)C(/C=C/C3=CN=CC=C3)=NC4=C1C=CC=C4
solubilityDMSO: ≥5 mg/mL
storage temp.2-8°C
Cas Number1290541-46-6
This product has met the following criteria to qualify for the following awards:



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