NPS2143 hydrochloride, >=98% (HPLC)

Code: SML0362-5MG D2-231

Application

NPS2143 hydrochloride has been used to study the function of calcium-sensing receptor :In the regulation of intestinal calcium transport.In the regulation of loca...


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€158.39 5MG
€194.82 inc. VAT
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Application

NPS2143 hydrochloride has been used to study the function of calcium-sensing receptor :In the regulation of intestinal calcium transport.In the regulation of local negative feedback of intestinal calcium absorption.In sensorimotor decision making during development.

Biochem/physiol Actions

NPS2143 is a selective calcium-sensing receptor (CaR) antagonist. The compound blocks increases in cytoplasmic calcium concentrations with an IC50 of 43 nM, and stimulates parathyroid hormone (PTH) secretion from bovine parathyroid cells over a wide range of extracellular calcuim concentrations.

NPS2143 is a phenylalkylamine calcilytic compound, and might be useful in treating autosomal dominant hypocalcemia. It serves as a blocking agent for hERG (human ether-a-go-go-related gene ) channel, CYP2D6 (cytochrome P450 2D6 ) and monoamine transporters.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
InChI keyZEBNDUQLNGYBNL-VEIFNGETSA-N
InChI1S/C24H25ClN2O2.ClH/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26;/h3-12,20,27-28H,13,15-16H2,1-2H3;1H/t20-;/m1./s1
optical activity[α]20/D +20 to +24°, c = 1.0 in methanol
Quality Level100
SMILES stringCl.CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc3cccc(Cl)c3C#N
solubilityDMSO: >10 mg/mL
storage temp.2-8°C
Cas Number324523-20-8
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